Ligand Technologies for Purifying COVID-19 Vaccines Reviving Market Growth

The latest advancements in downstream processing include ligand technologies for purifying RNA and COVID-19 vaccines. Companies in the downstream processing market are in many talks such as Navigo Proteins and Repligan, who have developed an affinity ligand targeting the SARS-CoV-2 spike protein for the purification of COVID-19 vaccines. They are focusing on the development and validation of a related affinity chromatography resin, which improves yield during the manufacturing of COVID-19 vaccines.

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In order to keep economies running, companies in the downstream processing market are developing platform-based purification solutions. They are taking efforts to innovate in affinity chromatography technologies that help to comply with increasing regulatory and capacity requirements of the entire biopharmaceutical manufacturing industry, including vaccines.

Improvements in Downstream Recovery Enhance Ultimate Process Yield for Drug Products

The downstream processing market is expected to cross US$ 25.4 Bn by the end of 2030 at a CAGR of ~13%. However, there is a need to remove bottlenecks associated with downstream production whilst achieving cost efficiency.

Companies in the downstream processing market are increasing efforts to improve raw materials characterization and use precisely controlled bioreactors to increase upstream yields. However, improvements in downstream throughput are not keeping pace with upstream, resulting in potential bottlenecks in end-to-end processes. Hence, companies are focusing on significant capital investments in order to create larger chromatography systems for managing large production volumes. Improvements in downstream recovery is emerging as a cost efficient way of enhancing ultimate process yield for drug products.

Single-use Systems Help Speed up Product Recovery, Simplify Downstream Operations

Single-use systems are helping to achieve low production quantities, improved target recovery, and increased conformation times. Membrane adsorbers and single-use chromatography columns are being highly publicized in the downstream processing market. This is evident since research laboratories are accustomed to disposable materials, such as pipettes and tubing, and has led to the acceptance of single-use filters, chromatography columns, and membrane adsorbers.

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New technologies such as spin-filters for product concentration or diafiltration are also helping to simplify downstream operations. This explains why the downstream processing market is projected to advance at a rapid pace during the forecast period. Single-use systems are helping to speed up product recovery for initial target design & confirmation and tests in animals.

Foam Fractionation Methods Help Evaluate Separation Efficiency of Biochemical Components

New process concepts and innovations in foam fractionation methods are grabbing the attention of stakeholders in the downstream processing market. For instance, Lehrstuhl für Anlagen- und Prozesstechnik – a university department in Garching bei München, Germany, is gaining recognition for its Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR) as alternative technique to classical ATPE. CPC is gaining popularity as a new technology for enzymatic reactions combined with simultaneous product separation.

Foam fractionation methods involve the evaluation of separation efficiency for biochemical components from complex fermentation broth. Companies in the downstream processing market are investigating hydrodynamic and adsorption kinetics in foam.

Advancements in Acoustophoresis Lead to Innovations in Ultrasonic Cell Separation

Innovations in technology and equipment have benefitted downstream processing. Advancements in acoustophoresis i.e. ultrasonic cell separation and high precision microfluidics for label-free cell selection are acting as key drivers for growth in the downstream processing market. Companies are gaining a strong research base in rapid gene delivery and in-line cell washing, which leads to significant productivity gains.

In order to accomplish cell separation on a clinical blood sample, companies in the downstream processing market are partnering with researchers to develop systems that perform acoustophoresis in high performance microfluidic devices. Such systems are bypassing the need for centrifugation. In the gene therapy space, companies are increasing efforts to develop microfluidic transduction modules that can co-localize viral vector around cells.

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Due to mass inoculation of COVID-19 vaccines being supplied from India, companies in the India downstream processing market are under scrutiny for using ligand technologies to purify vaccines. Companies are realizing that the ultimate goal of downstream optimization is to improve recovery and reduce the cost per gram of protein produced. However, the complexity of downstream production is affecting market growth, since finding efficiencies and economies of scale across downstream processing steps involves complex analysis and optimization. Hence, companies should investigate key aspects of current purification steps and technologies involving the use of mixed-mode and multimode chromatography resins. They are exploring ways to make chromatographic buffers more effective by using new kinds of additives.

Consistent Expansion of Biopharmaceutical and Biotechnology Industries to Boost Downstream Processing Market

Development of New Biotherapeutics with Smaller Molecular Weight to Drive Downstream Processing Market

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Limitations & Constraints in Producing Humanized Peptides to Hamper Downstream Processing Market

Downstream Processing Market: Regional Segmentation

Downstream Processing Market: Major Players

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