Acute kidney injury (AKI) is a complex syndrome, which results in a rapid loss of kidney function, affecting 1 in 5 patients (1) during hospitalization.
Four units at the University Hospital Heidelberg and Heidelberg Kidney Center implement Proenkephalin (penKid) in a pilot biomarker-based treatment approach to diagnose AKI faster and monitor it more accurately across departments.
PenKid is a proposed biomarker for real-time kidney function that potentially closes on the gaps of the standard diagnostic procedures.
HENNIGSDORF, GERMANY / ACCESSWIRE / August 26, 2022 / The diagnostic company SphingoTec GmbH (SphingoTec) announces the introduction of novel biomarker penKid in the clinical routine management of patients on a test basis in a total of four units at the University Hospital Heidelberg (UKHD) and Heidelberg Kidney Center (NZH). This includes the normal, the intermediate care (IMC), the nephrology, and the intensive care units (ICU) of both clinics in Heidelberg. According to recent data, the new diagnostic tool provides a faster and more accurate assessment of kidney function than current practice and aims to improve the management of patients with AKI. The condition is associated with high morbidity and mortality, and is a frequent complication of severe diseases, such as sepsis.
The pilot implementation of penKid was started in cooperation with the Clinic for Anesthesiology at UKHD and the NZH with the long-term goal of improving the monitoring of patient's kidney function. This routine use of penKid on a centralized level in the hospital drives innovation on multiple wards such as nephrology, ICU and IMC. The biomarker will be used on top of standard of care, in order to compare penKid with the existing standard diagnostics. Better and faster information assessment of kidney function helps detect AKI earlier, so that prompt action can be taken to protect renal function and improve patient prognosis.
Prof. Dr. med. Martin Zeier, Medical Director at NZH added, "After the first experience of penKid on the point of care analyzer from SphingoTec, we have decided to implement it in the central laboratory to apply the test in more patients at the same time. The goal is to investigate the added value compared to established renal function parameters in routine diagnostics. To date, our data suggest better and more direct information about kidney function, which may allow for more rapid action. Acute kidney injury is a serious condition that needs to be detected early and counteracted promptly. When the critically ill patients are undergoing renal replacement therapy, the decision to terminate the treatment is of high importance for the success of the therapy. With penKid we may achieve better insights that complement our current practices, and we have strong hopes that this will help us improve patient outcomes on short and long term."
PenKid is a promising biomarker to determine kidney function. It has been studied in over 55,000 patients showing the potential to reflect kidney function in real-time (2,3). Data from the PredARRT-Sep-Trial enrolling patients hospitalized in the surgical ICU of UKHD showed that penKid is a kidney function biomarker with rapid kinetics. According to these findings shared with the scientific community during the AKI&CRRT 2021 conference in San Diego US (4), penKid especially indicates changes in kidney function more dynamically than established functional markers. For those patients in critical conditions who require dialysis, penKid seems to be an early indicator of the kidney function and a potential tool to monitor kidney function and recovery during dialysis.
Prof. Dr. med. Markus Weigand, Medical Director of the Clinic for Anesthesiology at UKHD commented "On the ICU we experience the extreme of human disease, and AKI remains a serious complication in critically ill patients. A biomarker alerting changes in the kidney function faster than the currently known standards and uninfluenced by inflammation, has a significant potential for improving patient management. The sooner we identify a patient with kidney dysfunction, the faster we can intervene with life-saving procedures."
Dr. Andreas Bergmann, founder and CSO of SphingoTec added "Testing penKid in routine practice at University Hospital Heidelberg brings the scientific advancements directly to those needing them the most: the patients. AKI is usually diagnosed after symptoms manifest, with diagnostic tests that have limited ability to identify early the onset of the disease. The blind spots in diagnosing kidney dysfunction are well known to the medical community, therefore penKid is a functional biomarker that addresses a clear unmet need and provides actionable information on all stages of the disease evolution."
Wang HE, Muntner P, Chertow GM, Warnock DG. Acute kidney injury and mortality in hospitalized patients. Am J Nephrol. 2012;35(4):349-55. doi: 10.1159/000337487. Epub 2012 Apr 2. PMID: 22473149; PMCID: PMC3362180.
Beunders R et al. Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients. Shock. 2020;54(3):308-14.
Donato LJ et al. Analytical performance of an immunoassay to measure proenkephalin. Clin Biochem. 2018;58:72-7
https://www.crrtonline.com/conference/support/AKI&CRRT2021_Syllabus.pdf
SphingoTec GmbH ("SphingoTec"; Hennigsdorf near Berlin, Germany) develops and markets innovative in vitro diagnostic (IVD) tests for novel and proprietary biomarkers for the diagnosis, prediction and monitoring of acute medical conditions. SphingoTec's proprietary biomarker portfolio includes bioactive Adrenomedullin (bio-ADM), a unique biomarker for real-time assessment of endothelial function in conditions like sepsis or congestive heart failure, Proenkephalin (penKid), a unique biomarker for real-time assessment of kidney function, and Dipeptidyl Peptidase 3 (DPP3), a unique biomarker for cardiac depression. IVD tests for SphingoTec's proprietary biomarkers are made available as sphingotest® microtiter plate tests as well as point-of-care tests on the Nexus IB10 immunoassay platform by SphingoTec's subsidiary Nexus Dx Inc. (San Diego, CA, USA) alongside a broad menu of established and commonly used tests for acute and critical care.
Ulrike Glaubitz Sr. Public relations specialist SphingoTec GmbH Neuendorfstr. 15 A 16761 Hennigsdorf Tel. +49-3302-20565-0 press@sphingotec.com www.sphingotec.com
View source version on accesswire.com: https://www.accesswire.com/713608/Interdepartmental-Testing-of-the-Kidney-Function-Biomarker-PenKid-in-Routine-Care-at-Heidelberg-University-Hospital-and-the-Heidelberg-Kidney-Center
According to the World Health Organization, health officials are witnessing early signs that the new monkeypox case growth may be waning in Europe and the U.S. Public-health experts said they remain cautious about whether the outbreak has peaked as efforts continue to stretch limited vaccine supplies and protect vulnerable individuals. “If anything, we need to continue to strongly communicate and educate the public about this pathogen,” said Rodney Rohde, a public-health expert at Texas State Un
The Medicines and Healthcare products Regulatory Agency in the U.K. has granted expanded conditional approval for Novavax Inc's (NASDAQ: NVAX) COVID-19 vaccine, Nuvaxovid (NVX-CoV2373), in adolescents aged 12 through 17. The approval follows the FDA nod earlier this week. "As we start to prepare for a potential fall surge, we are pleased to offer the first protein-based COVID-19 vaccine to adolescents aged 12 through 17 in the U.K.," said Stanley C. Erck, President, and CEO, of Novavax. The expa
Merck's rumored takeover of cancer-focused biotech Seagen has stalled on price, according to a report Friday that sent SGEN stock tumbling.
Novartis (NVS) plans to spin off its generics division, Sandoz. The FDA approves J&J (JNJ) and AbbVie's (ABBV) Imbruvica for pediatric indication cGVHD.
Iovance (IOVA) starts a rolling BLA submission with the FDA seeking approval for its lead pipeline candidate in advanced melanoma patients. The filing is expected to be completed by fourth-quarter 2022.
(Bloomberg) -- Merck & Co.’s talks to buy cancer-drug maker Seagen Inc. have stalled for now, threatening what would be the pharmaceutical giant’s biggest deal in more than a decade, according to people familiar with the matter.Most Read from BloombergNearly 60,000 Sneakers in $85 Million Ponzi Scheme to Go on SaleGOP Fury Over ESG Triggers Backlash With US Pensions at RiskFed’s Jackson Hole Conference Is Underway: Here’s What to ExpectWorld’s Most Popular Password Manager Says It Was HackedA 12
Teladoc Health (NYSE: TDOC) the global leader in whole-person virtual care, together with Cloud DX (TSXV: CDX) (OTC: CDXFF), a leading remote patient monitoring ("RPM") platform, are pleased to announce that they have entered into a strategic partnership to better serve the remote monitoring needs of patients across Canada.
SIGA has received $60 million in orders for Tpoxx, which was developed to treat smallpox in the event of an attack.
The study was presented to the American Chemical Society on Wednesday.
Lynda Bluestein, 75, said she is determined not to lose control over her end-of-life care
"I see plenty of people presenting with understated symptoms that turn out to be advanced diseases — but that one left a mark on my soul."View Entire Post ›
Doctors are observing a person diagnosed with all three viruses within a very short window of time.
Based on the positive data from the phase III study on its RSV vaccine candidate, Pfizer plans to file a biologics license application (BLA) to the FDA in fall 2022.
Can you strengthen your immune system? Yes. There is genetic influence, but how you live, and your environment also is important. Here's what to know.
Bristol Myers (BMY) has put up an impressive performance so far in 2022, and the momentum should continue on label expansion of existing drugs.
Statins provide limited use unless patients stay on them for life, research suggests.
A newly obtained autopsy report confirms prior announcements of how country singer died
Wake County Public Health said it has confirmed cases of monkeypox in two women, the first known cases in the state.
Amazon shifts its emphasis as it plans to halt one of its key health initiatives by the end of 2022.
PanTher Therapeutics, a startup behind drugs for pancreatic and other types of cancer, is relocating to Texas.